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Product Review of Ortho Core

Updated on 2nd June 2009 by Dr Charles Tweed

AOR have produced a truly excellent supplement here in Ortho Core. The rationale behind its balance, is in our opinion, spot on and it contains pretty much everything one would need (See our Supplements Page). The philosophy behind its design reflects ours here at aging-management.com and we are all regular users.

Certain points are worth mentioning on the composition of vitamins:

The Vitamin A is primarily provided as natural carotenoids. Vitamin A supplementation has been found, in reasonably constructed studies, to be associated with a non-statistical decrease in survival. Whilst this is not conclusive proof to avoid Vitamin A supplementation it certainly gives pause for thought and would suggest high dose Vitamin A supplementation is to be avoided. One of the benefits of consuming carotenoids is that they release their vitamin A content slowly into the body, and only as Vitamin A stores are used up. In addition, each of those included here are strongly associated with better health outcomes, ranging from cardiovascular disease (lycopene), to macular degeneration and other degenerative eye conditions (Zeaxanthin and astaxanthin).
The B – vitamins are provided in a sensible dose ratio which has more to do with the body's requirements than the cost and ease of inclusion into a supplement. It also includes inositol, choline and biotin, which many supplements do not.
The Vitamin E is not just provided as alpha tocopherol. As many of you will know, vitamin E is actually a combination of 8 compounds: 4 tocopherols, and 4 tocotrienols. The exact combination of doses of components that is best is unclear. Epidemiological data suggest consumption of a diet containing foods high in vitamin E content is beneficial, intervention trials suggest alpha-tocopherol alone does not reproduce these benefits, and may even be harmful if given without the rest of the tocotrienols and tocopherols.
Ortho Core contains a reasonable dose of Vitamin D. It is fascinating to see how Vitamin D has been found to influence also sorts of disease processes, and recommendations have been made to increase the RDI and maximum levels. For a full discussion of Vitamin D, please see the aging-management.com Assessment of Vitamin D.

Ortho Core provides trace minerals at sensible levels.

Also included in Ortho Core are three powerful botanical agents that are likely to significantly reduce the risk of cancers, cardiovascular disease, skin aging and lung problems:

Preliminary studies of Sulforaphane have been very exciting. Sulforaphane seems to be active against breast and lung cancer and also reduce the damage that cigarettes do to the lungs. We also suggest you include broccoli sprouts in your diet and other Brassica vegetables, to maximise the benefits of this group of compounds.
The other compound is pomegranate extract. The bulk of pomegranate’s proven benefits are in the areas of prostate cancer and cardiovascular disease. I am confident that it will also be found to be helpful in suppressing the initiation and promotion of other cancers. There is broad support for this in cancer cell line studies but clinical studies have not yet been done. Again, consuming pomegranate juice is also a smart way to maximise the benefits.
Resveratrol has been reviewed at the aging-management.com Assessment of Resveratrol. We suggest using a higher dose than included in Ortho Core. The optimum dose is a matter for negotiation. One side would suggest that the best proof for it’s anti-aging effects are for relatively high doses as demonstrated by Sinclair's studies. This would correspond to between 250mg – 500mg per day for an adult human. The other suggestion is that improvements in many of the intermediate markers and expressions of gene coding is seen at much more modest dosages. Some authorities would counter that is seen as low as 2-4mg per day. The answer is not clear at this stage but the best evidence would suggest erring towards the higher bracket.

Other nutrients with excellent and well documented benefits that are included in Ortho Core are:

Alpha lipoic acid is a superb supplement and has been reviewed in detail at the aging-management.com Assessment of Alpha Lipoic Acid. Users may wish to increase the dosage a little, and we strongly recommend using it in combination with Acetyl L Carnitine.
N-Acetylcysteine is a potent inhibitor of oxidant induced organ damage and mitochondrial protectant. It is widely used in modern medicine to prevent and try and reverse the damage caused by toxic drugs. This can range from paracetamol (acetominophen) overdose, to chemotherapeutic agents and contrast “dyes” used it scans. Good studies supporting its use in the realm of disease prevention are scarce but the mechanism of action is cause for confidence and it appears safe for chronic use.
Lastly, but by no means least, is green tea extract. Green tea extract is one of my favourite supplements. The EGCG content appears to be another performer across multiple systems. Photo-aging and skin cancers, delayed aging and increased longevity, better cardiovascular function, improved outcomes with neurodegenerative delay, weight loss and possibly helpful in preventing cancer. A very impressive list of attributes for a single compound.

So in conclusion, Ortho Core is a superb way to get many of the best ingredients into your daily routine, without having to fiddle around with numerous pill bottles. For the reasons discussed, Ortho Core has become the product of choice amongst informed life-extentionists for covering the basics and more. We are pleased to be able to bring you AOR Ortho Core, for what we believe is the the best price in the UK and Europe if you are buying a 3 month supply. We encourage you to use Ortho Core as the bedrock of your daily supplement regime.

You can buy Ortho Core from this page:

http://aging-management.com/allprods.php?fl=O